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Palancade Lab – Puzzling out nuclear pore complex assembly

Home publis, News17 August 2023
The Palancade lab recently published a new article in FEBS Letters: Puzzling out nuclear pore complex assembly Abstract:  Nuclear pore complexes (NPCs) are sophisticated multiprotein assemblies embedded within the nuclear envelope and controlling the exchanges of molecules between the cytoplasm and the nucleus. In this review, we summarize the mechanisms by which these elaborate complexes are built…

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Post-doc position to study collagen secretion in healthy or fibrotic cells (M/W)

News17 August 2023
Contract Period : 24 months Expected date of employment : 1 December 2023 Apply before August, 31st 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-ISHRAO-001/Default.aspx?lang=EN Missions A post-doctoral research position is available in the "Intracellular compartmentalisation" team at the Institut Jacques Monod (UMR7592CNRS/Université Paris Cité, Paris, France) to work on a project that will study the secretion of extracellular matrix proteins. All animals have an…

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Dumont Lab – An unconventional TOG domain is required for CLASP localization

Home publis, News31 July 2023
The Dumont Lab recently published an article in Current Biology: An unconventional TOG domain is required for CLASP localization Abstract: Cytoplasmic linker-associated proteins (CLASPs) form a conserved family of microtubule-associated proteins (MAPs) that maintain microtubules in a growing state by promoting rescue while suppressing catastrophe.1  CLASP function involves an ordered array of tumor overexpressed gene (TOG)…

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Post-doc in bioinformatics to study the evolution of Arf family GTPases and their regulators (M/W)

Uncategorized28 July 2023
Contract: 12 months Expected date of employment: 15 September 2023 Apply before August, 11th 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-CATJAC-004/Default.aspx?lang=EN Missions The post-doc will be involved in bioinformatics research into the functions of regulators of membrane dynamics in eukaryotic cells. In particular, the project will focus on the functions of the Arf family of GTPase regulators, from archaea to eukaryotes. Activities - Search…

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Postdoctoral fellow in structural analysis of proteins by mass spectrometry M/W

Uncategorized28 July 2023
Contract Period: 24 months Expected date of employment: 11 September 2023 Apply before August, 14th 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-GUICHE-002/Default.aspx?lang=EN Missions The person recruited will be responsible for developing and carrying out analyses of intact proteins by mass spectrometry using innovative technologies such as native MS, ion mobility, ECD and SID fragmentation and high-resolution chromatography. Activities The person recruited will develop and…

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Research Engineer Position (M/W)

Uncategorized28 July 2023
Contract duration: 1 year Contract start date: September 11, 2023 Apply before August 15: https://emploi.cnrs.fr/Offres/CDD/UMR7592-BENPAL-008/Default.aspx We are looking for a highly-motivated Research Engineer to be in charge of the DECODERS project, supported by the Labex who am I? (http://www.labex-whoami.org/en/) and hosted by the Institut Jacques Monod (CNRS/Université Paris Cité, Paris 13e, France). Several research groups from the Labex consortium…

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Greenberg Lab – A genome-wide screen reveals new regulators of the 2-cell-like cell state

Home publis, News26 July 2023
The Greenberg Lab recently contributed to the publication of a new article in Nature Structural & Molecular Biology: A genome-wide screen reveals new regulators of the 2-cell-like cell state Abstract: In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse ‘2-cell-like cells’ (2CLCs), which appear at…

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Pintard Lab – Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos

Home publis, News24 July 2023
The Pintard  lab rencently published in Science Advances: Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos Abstract: The nuclear envelope, which protects and organizes the genome, is dismantled during mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the parental pronuclei is spatially and temporally regulated during mitosis…

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Cadoret Lab – Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner

Home publis, News20 July 2023
The Cadoret Lab recently published in International Journal of Molecular Sciences : Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Abstract: Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F pathway and induce…

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Minc Lab – Length limitation of astral microtubules orients cell divisions in murine intestinal crypts

Home publis, News10 July 2023
The Minc Lab recently published a new article in Developmental Cell: Length limitation of astral microtubules orients cell divisions in murine intestinal crypts Abstract: Planar spindle orientation is critical for epithelial tissue organization and is generally instructed by the long cell-shape axis or cortical polarity domains. We introduced mouse intestinal organoids in order to study spindle…

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