L'ancienne équipe Camadro et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans Cell Reports Medicine : SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism Résumé : Inborn errors of vitamin B12 metabolism (IECM) resulting from impaired methionine synthase (MTR) activity cause severe cognitive and…

L'équipe Ladoux/Mège a contribué à la publication d'un nouvel article dans Materials Horizons : Thermal-driven H-bond reconfiguration for bioinspired high-strength anisotropic supramolecular hydrogels Résumé : Natural anisotropic tissues, such as tendons and cartilages, achieve remarkable mechanical properties and various biofunctions through oriented hierarchical structures. Inspired from organisms, we develop a synergistic molecular and structural engineering technique based…

L'équipe Minc a publié un nouvel article dans Molecular Biology of the Cell : A cross-species analysis of cell wall mechanosensors Résumé : The Cell Wall (CW) protects fungal cells from various challenges making its integrity essential for cell survival. CW integrity is monitored by transmembrane sensors that activate effectors to promote CW synthesis in response to…

L'équipe Léon a contribué à la publication d'un nouvel article dans Journal of Cell Biology : Ist2 is a phospholipid scramblase that links lipid transport at the ER to organelle homeostasis Résumé : Lipid scramblases allow passive flip-flop of phospholipids between bilayer leaflets, thereby promoting membrane symmetry. At the endoplasmic reticulum (ER), where phospholipid synthesis is restricted…

L'équipe Pintard a contribué à la publication d'un nouvel article dans Journal of Biological Chemistry : The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation Résumé : SETD2 is the primary methyltransferase responsible for generating H3K36me3, an epigenetic mark that is essential for transcriptional regulation and chromatin integrity. SETD2 mutations are frequently observed…

L'équipe Konstantinides a publié un nouvel article dans Developmental Biology : Gene expression cartography of a developing neuronal structure Résumé : Brains are complex structures comprising thousands to billions of neurons that belong to thousands of different neuronal types. These neurons often come from different progenitor domains and have very diverse developmental histories, yet they need…

L'équipe Ladoux/Mège et la plateforme ImagoSeine ont contribué à la publication d'un nouvel article dans PNAS : Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion Résumé : Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is known to strongly alter macromolecule mobility, how cytoplasmic structures physically…

L'équipe Cadoret a contribué à un nouvel article publié dans Nature Communications : DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains Abstract : Besides genome-wide patterns of replication timing (RT), some genes display allelic replication asynchrony in stem cells, brought about by stochastic events and genetic polymorphisms. Whether epigenetic modifications control…

L'équipe Guichet a publié un nouvel article dans Development : Girdin controls the pace of 3D tracheal cell intercalation by coupling adherens junctions to the actin cytoskeleton in Drosophila Résumé : Morphogenesis is orchestrated through coordinated cell movements, including cell intercalation, which drives extensive changes in cell shape and position. This process requires precise regulation of interactions…

L'équipe Ladoux/Mege a publié un nouvel article dans The European Physical Journal E  Tissue stress measurements with Bayesian inversion stress microscopy Résumé : Cells within biological tissue are constantly subjected to dynamic mechanical forces. Measuring the internal stress of tissues has proven crucial for our understanding of the role of mechanical forces in fundamental biological processes…