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ImagoSeine – Altered X-chromosome inactivation predisposes to autoimmunity

Les dernières publications13 mai 2024
La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Science Advances : Altered X-chromosome inactivation predisposes to autoimmunity   Résumé : In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases, while females are more susceptible to systemic autoimmunity. X-chromosome inactivation (XCI), the epigenetic mechanism ensuring the…

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Séminaire IJM – Ezzat El-Sherif – 21/06/2024

Actualités10 mai 2024
Invité par l'équipe Konstantinides, Ezzat El-Sherif (School of Integrative Biological and Chemical Sciences, University of Texas Rio Grande Valley, Edinburg, Texas, US) présentera un Séminaire de l'Institut Jacques Monod sur le thème : How enhancers translate time into space during development   Résumé : In embryonic development, is time more important or space? Conventionally, the answer would be:…

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Séminaire IJM – Matthias Peter – 18/06/2024

Actualités, Les dernières actualités6 mai 2024
Le mardi 18 juin 2024, le Labex WHO AM I? invite le Professeur Matthias Peter (Institute of Biochemistry, ETH Zurich) pour présenter un séminaire de l’Institut Jacques Monod sur le thème : Ubiquitin tails   Résumé : We are interested in the function of E3-ubiquitin ligases orchestrating diverse cellular processes. For many years, we characterized the regulation and function of Cullin-RING E3…

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Séminaire IJM – Nick Irwin – 7/06/2024

Actualités, Les dernières actualités6 mai 2024
Invité par l'équipe Duharcourt, Nick Irwin (Gregor Mendel Institute, Vienna BioCenter) présentera un séminaire de l'Institut Jacques Monod sur le thème : Self-assembling viral histones unravel early nucleosome evolution   Résumé : The nucleosome is a defining feature of eukarytoes that plays a central role in the coordination and regulation of the genome. Accordingly, understanding the origin of…

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Microphysio24: From organoids to organs-on-chips

Actualités, Les dernières actualités6 mai 2024
Microphysio24: From organoids to organs-on-chips The 2nd edition of the MicroPhysio conference on "Micro-physiological models: From organoids to organs-on-chip"  will take place at the CNRS center in Cargèse (www.iesc.univ-corse.fr) from September 23rd to September 27th, 2024. It is becoming increasingly clear that even the best in vivo models such as genetically-modified mouse models or orthotopic patient-derived xenografts cannot recapitulate the full complexity of human…

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ImagoSeine – CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT

Actualités, Les dernières publications3 mai 2024
La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Circulation : CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT   Résumé : BACKGROUND: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug…

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Dumont Lab – Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane

Actualités, Les dernières publications3 mai 2024
L'équipe Dumont a contribué à la publication d'un nouvel article dans Molecular Biology of Cell : Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane   Résumé : Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of…

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Ribes Lab – Non-Mammalian Models for Understanding Neurological Defects in RASopathies

Actualités, Les dernières publications29 avril 2024
L'équipe Ribes a contribué à la publication d'une revue dans Biomedicines : Non-Mammalian Models for Understanding Neurological Defects in RASopathies   Résumé : RASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders. Afflicting approximately one in a thousand newborns, RASopathies manifest…

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