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Collignon Lab – Dissecting signaling hierarchies in the patterning of the mouse primitive streak using micropatterned EpiLC colonies

Home publis27 June 2022
Congratulations to the Collignon Team for this new paper just published in Stem Cell Reports! Dissecting signaling hierarchies in the patterning of the mouse primitive streak using micropatterned EpiLC colonies Summary Embryo studies have established that the patterning of the mouse gastrula depends on a regulatory network in which the WNT, BMP, and NODAL signaling pathways cooperate,…

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Romet-Lemonne / Jégou Lab: Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles

Home publis, News24 May 2022
Congratulations to Romet-Lemonne / Jégou Team for this new paper just published in JoVE: Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles Abstract In order to decipher the complex molecular mechanisms that regulate the assembly and disassembly of actin filaments, it is a great asset to monitor individual…

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Ribes Lab – Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs

Home publis, News24 May 2022
Congratulations to the Ribes Team for this new paper just published in PLOS Genetics!   Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs   Abstract The hallmarks of the alveolar subclass of rhabdomyosarcoma are chromosomal translocations that generate chimeric PAX3-FOXO1 or PAX7-FOXO1 transcription factors. Overexpression of either PAX-FOXO1s results in related cell transformation in animal models. Yet,…

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Libri Lab: A Modified Cross-Linking Analysis of cDNAs (CRAC) Protocol for Detecting RNA–Protein Interactions and Transcription at Single-Nucleotide Resolution

Home publis9 May 2022
Just published in Yeast Functional Genomics  pp 35-55 A Modified Cross-Linking Analysis of cDNAs (CRAC) Protocol for Detecting RNA–Protein Interactions and Transcription at Single-Nucleotide Resolution by: Drice Challal Jessie Colin Tommaso Villa Domenico Libri   Abstract Detecting protein–RNA interactions in vivo is essential for deciphering many important cellular pathways. Several methods…

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Camadro Lab / ProtéoSeine: Quantitative Proteomics in Yeast : From bSLIM and Proteome Discoverer Outputs to Graphical Assessment of the Significance of Protein Quantification Scores

Home publis9 May 2022
Just publisehd in Yeast Functional Genomics  pp 275-292   Quantitative Proteomics in Yeast : From bSLIM and Proteome Discoverer Outputs to Graphical Assessment of the Significance of Protein Quantification Scores By Nicolas Sénécaut Pierre Poulain Laurent Lignières Samuel Terrier Véronique Legros Guillaume Chevreux Gaëlle Lelandais Jean-Michel Camadro

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Pintard Lab: The kiss of life: Aurora A embraces the phosphate of its cofactor Bora to trigger mitotic entry

Home publis9 May 2022
A new paper published dans médecine/sciences par l'équipe Pintard : The kiss of life: Aurora A embraces the phosphate of its cofactor Bora to trigger mitotic entry   La plupart des organismes vivants pluricellulaires sont constitués d’un grand nombre de cellules très différentes. À l’exception des gamètes, qui sont le produit d’une division cellulaire particulière (méiose), toutes…

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Duharcourt Lab – Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements

Home publis21 April 2022
A new paper published by Duharcourt Team in Developmental Cell! Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements   Summary Polycomb repressive complex 2 (PRC2) maintains transcriptionally silent genes in a repressed state via deposition of histone H3K27-trimethyl (me3) marks. PRC2 has also been implicated in silencing transposable elements (TEs), yet how PRC2…

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Konstantinides Lab: A complete temporal transcription factor series in the fly visual system

Home publis, News7 April 2022
A new paper just published in Nature by Nikos Konstantinides! Congratulations to all the authors   A complete temporal transcription factor series in the fly visual system   Abstract The brain consists of thousands of neuronal types that are generated by stem cells producing different neuronal types as they age. In Drosophila, this temporal patterning is driven by the successive expression…

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Courtier Lab: Non-visual cues and indirect strategies that enable discrimination of asymmetric mates

Home publis, News6 April 2022
Congratulations to Roshan Kumar Vijendravarma (Courtier Lab) for this new article published with Pierre Leopold (Institut Curie) in Ecology and Evolution: Non-visual cues and indirect strategies that enable discrimination of asymmetric mates   Abstract The postulates of developmental instability–sexual selection hypothesis is intensely debated among evolutionary biologists, wherein despite a large amount of empirical data, evidence for…

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Duharcourt Lab: GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium

Home publis, News5 April 2022
A new paper just published by Duharcourt Team in Genome Research! GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium   Abstract Eukaryotic genes are interrupted by introns that must be accurately spliced from mRNA precursors. With an average length of 25 nt, the more than 90,000 introns of Paramecium tetraurelia stand among the…

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