Le  Ladoux / Mège recently contributed to the publication of a new article in Nature Cell biology : A mechanosensitive caveolae–invadosome interplay drives matrix remodelling for cancer cell invasion Abstract: Invadosomes and caveolae are mechanosensitive structures that are implicated in metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix degradative invadosomes at contact…

The Camadro Lab recently contributed to the publication of a new article in Briefing in Bioinformatics : The five pillars of computational reproducibility: bioinformatics and beyond   Abstract: Computational reproducibility is a simple premise in theory, but is difficult to achieve in practice. Building upon past efforts and proposals to maximize reproducibility and rigor in bioinformatics, we present…

The Courtier Lab recently published a new article in Current Opinion in Insect Science : The loci of insect phenotypic evolution   Abstract: Insects are important elements of terrestrial ecosystems because they pollinate plants, destroy crops, transmit diseases to livestock and humans, and are important components of food chains. Here, I used Gephebase, a manually curated database of…

The Grange/Geigl Lab published a new article in Nature Ecology and Evolution :  Genome sequences of 36-37,000 year-old modern humans at Buran-Kaya III in Crimea Two 36 and 37,000-year-old genomes from Crimea shed light on the first successful implantations of modern Humans in Europe and on the emergence of the Gravettian culture The implantation of anatomically…

The Gazave Lab recently published a new article in BMC Genomics: Transcriptomic landscape of posterior regeneration in the annelid Platynereis dumerilii Abstract: Background Restorative regeneration, the capacity to reform a lost body part following amputation or injury, is an important and still poorly understood process in animals. Annelids, or segmented worms, show amazing regenerative capabilities, and as…

The Palancade Lab  recently published a new article in Nature  communications : A R-loop sensing pathway mediates the relocation of transcribed genes to nuclear pore complexes   Abstract: Nuclear pore complexes (NPCs) have increasingly recognized interactions with the genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By combining genome-wide approaches with live imaging…

The Ladoux/Mège recently contributed to the publication of an article in Nature Communications :  Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density Abstract: Changes in tissue geometry during developmental processes are associated with collective migration of cells. Recent experimental and numerical results suggest that these changes could leverage on the coexistence of nematic…

The Conduit Lab and the Guichet Lab recently published in Journal of Cell Biology : Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes Abstract: Microtubule nucleation is mediated by γ-tubulin ring complexes (γ-TuRCs). In most eukaryotes, a GCP4/5/4/6 “core” complex promotes γ-tubulin small complex (γ-TuSC) association to generate cytosolic γ-TuRCs. Unlike γ-TuSCs, however,…

The Azimzadeh Lab recently published in Current Biology : Evolution: The ancient history of cilia assembly regulation Abstract: A new study identifies a conserved regulatory mechanism for cilia assembly in the closest unicellular relatives of animals, suggesting that this mechanism was already present in a common unicellular ancestor and was repurposed during the transition to multicellularity.

The Doye Lab recently contributed to the publication of a new article in DNA Repair: Metazoan nuclear pore complexes in gene regulation and genome stability Abstract: The nuclear pore complexes (NPCs), one of the hallmarks of eukaryotic nuclei, allow selective transport of macromolecules between the cytoplasm and the nucleus. Besides this canonical function, an increasing number of additional roles have…