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Jackson/Verbavatz Lab – The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

Home publis, News7 March 2024
The Jackson/Verbavatz Lab published a new article eLife: The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions   Abstract: Cell motility processes highly depend on the membrane distribution of Phosphoinositides, giving rise to cytoskeleton reshaping and membrane trafficking events. Membrane contact sites serve as platforms for direct lipid exchange…

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Courtier Lab – CNCA aligns small annotated genomes

Home publis, News4 March 2024
The Courtier Lab contributed to a new article published in BMC Bioinformatics : CNCA aligns small annotated genomes   Abstract: Background To explore the evolutionary history of sequences, a sequence alignment is a first and necessary step, and its quality is crucial. In the context of the study of the proximal origins of SARS-CoV-2 coronavirus, we wanted to…

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JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development

Home publis27 February 2024
A new article has been published in Nature Communications: JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development This study is the result of a collaboration between scientists of the Institut de biologie intégrative de la cellule (université Paris-Saclay) and Institut Jacques Monod (Konstantinides Lab, Minc Lab, Guichet Lab).   Abstract: The number of embryonic…

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Pintard Lab – Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans

Home publis, News13 February 2024
The Pintard lab recently published a new article in Journal of Cell Biology: Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans   Abstract: Microtubule-severing enzymes (MSEs), such as Katanin, Spastin, and Fidgetin play essential roles in cell division and neurogenesis. They damage the microtubule (MT) lattice, which can either destroy or amplify the…

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Courtier Lab – Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences

Home publis, News13 February 2024
The Courtier lab recently published a new article in BMC Ecology and Evolution: Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences Abstract: Background During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood. Here we examine…

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Wassmann Lab – Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast

Home publis, News13 February 2024
The Wassmann lab published a new article in EMBO: Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast   Abstract: Exit from mitosis is brought about by dramatic changes in the phosphoproteome landscape. A drop in Cyclin-dependent kinase (Cdk) activity, the master regulatory kinase, and activation of counteracting phosphatases such as Cdc14 in budding…

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Romet-Lemonne/Jégou Lab – Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

Home publis, News29 January 2024
The Romet-Lemonne/Jégou Lab contributed to the publication of a new article in Nature structural & molecular biology: Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament   Résumé: Regulation of the assembly and turnover of branched actin filament networks nucleated by the Arp2/3 complex is essential during many cellular processes, including cell migration and…

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Romet-Lemonne/Jégou Lab – Regeneration of actin filament branches from the same Arp2/3 complex

Home publis, News29 January 2024
The Romet-Lemonne/Jégou Lab published a new article in Science Advances: Regeneration of actin filament branches from the same Arp2/3 complex Abstract: Branched actin filaments are found in many key cellular structures. Branches are nucleated by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to the side of preexisting “mother” filaments. Over time, branches dissociate…

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