The Greenberg contributed to the publication of a new article in Nature Structural & Molecular biology: DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation   Abstract: As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation levels. During this transition, the germline is…

The Camadro lab and the ProtéoSeine platform contirbuted to the publication of a new article in eBioMedicine: Multiomic analysis in fibroblasts of patients with inborn errors of cobalamin metabolism reveals concordance with clinical and metabolic variability   Abstract: Background The high variability in clinical and metabolic presentations of inborn errors of cobalamin (cbl) metabolism (IECM), such as the cblC/epicblC types with…

The Raote lab contributed to the publicaiton of a new article in PNAS : A model for collagen secretion by intercompartmental continuities   Abstract: Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too large for export by the standard COPII-coated vesicle of 60…

The Balavoine Lab recently published a new article in Plos One: Fast cycling culture of the annelid model Platynereis dumerilii   Abstract: Platynereis dumerilii, a marine annelid, is a model animal that has gained popularity in various fields such as developmental biology, biological rhythms, nervous system organization and physiology, behaviour, reproductive biology, and epigenetic regulation. The transparency of P. dumerilii tissues…

The Ribes Lab published a new article in Emerging topics in life sciences: Stem cell-derived models of spinal neurulation   Abstract: This review is the fruit of an enriching collaboration with my thesis supervisors Vanessa Ribes and Stéphane Nedelec (Institut du Fer à Moulin), along with Martin Catala (Institut de Biologie Paris Seine) and Mikaëlle Bocel (Institut Jacques…

The Courtier lab recently published a new article in Plos one: Recommended distances for physical distancing during COVID-19 pandemics reveal cultural connections between countries   Abstract: During COVID-19 pandemic several public health measures were implemented by diverse countries to reduce the risk of COVID-19, including social distancing. Here we collected the minimal distance recommended by each country for…

The Léon lab contributed to a new article published in Molecular Cell: Ubiquiton - An inducible, linkage-specific polyubiquitylation tool   Abstract: The posttranslational modifier ubiquitin regulates most cellular processes. Its ability to form polymeric chains of distinct linkages is key to its diverse functionality. Yet, we still lack the experimental tools to induce linkage-specific polyubiquitylation of a protein…

The Camadro Lab published a new article in NAR Genomics & Bioinformatics: 3D models of fungal chromosomes to enhance visual integration of omics data   Abstract: The functions of eukaryotic chromosomes and their spatial architecture in the nucleus are reciprocally dependent. Hi-C experiments are routinely used to study chromosome 3D organization by probing chromatin interactions. Standard representation of…

The Borghi Lab contributed to a new article published in Experimental Hematology & Oncology: ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells   Abstract: Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition to reducing…

The Collignon Lab recently published a new article in Non-coding RNA : LADON , a Natural Antisense Transcript of NODAL , Promotes Tumour Progression and Metastasis in Melanoma   Abstract: The TGFβ family member NODAL, repeatedly required during embryonic development, has also been associated with tumour progression. Our aim was to clarify the controversy surrounding its involvement in melanoma…