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JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development

Home publis27 February 2024
A new article has been published in Nature Communications: JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development This study is the result of a collaboration between scientists of the Institut de biologie intégrative de la cellule (université Paris-Saclay) and Institut Jacques Monod (Konstantinides Lab, Minc Lab, Guichet Lab).   Abstract: The number of embryonic…

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Pintard Lab – Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans

Home publis, News13 February 2024
The Pintard lab recently published a new article in Journal of Cell Biology: Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans   Abstract: Microtubule-severing enzymes (MSEs), such as Katanin, Spastin, and Fidgetin play essential roles in cell division and neurogenesis. They damage the microtubule (MT) lattice, which can either destroy or amplify the…

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Courtier Lab – Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences

Home publis, News13 February 2024
The Courtier lab recently published a new article in BMC Ecology and Evolution: Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences Abstract: Background During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood. Here we examine…

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Wassmann Lab – Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast

Home publis, News13 February 2024
The Wassmann lab published a new article in EMBO: Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast   Abstract: Exit from mitosis is brought about by dramatic changes in the phosphoproteome landscape. A drop in Cyclin-dependent kinase (Cdk) activity, the master regulatory kinase, and activation of counteracting phosphatases such as Cdc14 in budding…

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Romet-Lemonne/Jégou Lab – Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

Home publis, News29 January 2024
The Romet-Lemonne/Jégou Lab contributed to the publication of a new article in Nature structural & molecular biology: Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament   Résumé: Regulation of the assembly and turnover of branched actin filament networks nucleated by the Arp2/3 complex is essential during many cellular processes, including cell migration and…

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Romet-Lemonne/Jégou Lab – Regeneration of actin filament branches from the same Arp2/3 complex

Home publis, News29 January 2024
The Romet-Lemonne/Jégou Lab published a new article in Science Advances: Regeneration of actin filament branches from the same Arp2/3 complex Abstract: Branched actin filaments are found in many key cellular structures. Branches are nucleated by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to the side of preexisting “mother” filaments. Over time, branches dissociate…

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Greenberg lab – DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation

Home publis, News5 January 2024
The Greenberg contributed to the publication of a new article in Nature Structural & Molecular biology: DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation   Abstract: As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation levels. During this transition, the germline is…

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Camadro Lab / ProtéoSeine – Multiomic analysis in fibroblasts of patients with inborn errors of cobalamin metabolism reveals concordance with clinical and metabolic variability

Home publis, News5 January 2024
The Camadro lab and the ProtéoSeine platform contirbuted to the publication of a new article in eBioMedicine: Multiomic analysis in fibroblasts of patients with inborn errors of cobalamin metabolism reveals concordance with clinical and metabolic variability   Abstract: Background The high variability in clinical and metabolic presentations of inborn errors of cobalamin (cbl) metabolism (IECM), such as the cblC/epicblC types with…

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