The Conduit Lab and the Guichet Lab recently published in Journal of Cell Biology : Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes Abstract: Microtubule nucleation is mediated by γ-tubulin ring complexes (γ-TuRCs). In most eukaryotes, a GCP4/5/4/6 “core” complex promotes γ-tubulin small complex (γ-TuSC) association to generate cytosolic γ-TuRCs. Unlike γ-TuSCs, however,…

The Azimzadeh Lab recently published in Current Biology : Evolution: The ancient history of cilia assembly regulation Abstract: A new study identifies a conserved regulatory mechanism for cilia assembly in the closest unicellular relatives of animals, suggesting that this mechanism was already present in a common unicellular ancestor and was repurposed during the transition to multicellularity.

The Doye Lab recently contributed to the publication of a new article in DNA Repair: Metazoan nuclear pore complexes in gene regulation and genome stability Abstract: The nuclear pore complexes (NPCs), one of the hallmarks of eukaryotic nuclei, allow selective transport of macromolecules between the cytoplasm and the nucleus. Besides this canonical function, an increasing number of additional roles have…

The Greenberg Lab contributed to the publication of a new article in Nucleic Acids Research: A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation   Abstract:  Epigenetic mechanisms are essential to establish and safeguard cellular identities in mammals. They dynamically regulate the expression of genes, transposable elements and higher-order chromatin structures. Consequently,…

The Prioleau Lab contributed to the publication of a new article in Nature communications : Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair Abstract: Histone post-translational modifications promote a chromatin environment that controls transcription, DNA replication and repair, but surprisingly few phosphorylations have been documented. We report the discovery of histone H3 serine-57…

The Palancade Lab contributed to the publication of a new article in Plos Genetics : Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import Abstract: N-terminal ends of polypeptides are critical for the selective co-translational recruitment of N-terminal modification enzymes. However, it is unknown whether specific N-terminal signatures differentially regulate protein…

The Prioleau Lab recently published a new article in dans Nature Communications: Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates Abstract: Replication of vertebrate genomes is tightly regulated to ensure accurate duplication, but our understanding of the interplay between genetic and epigenetic factors in this regulation remains incomplete. Here, we investigated the involvement of three…

The Veitia Lab recently published a new article in BioEssays : Dominant negative variants and cotranslational assembly of macromolecular complexes Abstract: Pathogenic variants occurring in protein-coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency. Dominant-negative (DN)…

The Palancade lab recently published a new article in FEBS Letters: Puzzling out nuclear pore complex assembly Abstract:  Nuclear pore complexes (NPCs) are sophisticated multiprotein assemblies embedded within the nuclear envelope and controlling the exchanges of molecules between the cytoplasm and the nucleus. In this review, we summarize the mechanisms by which these elaborate complexes are built…

The Dumont Lab recently published an article in Current Biology: An unconventional TOG domain is required for CLASP localization Abstract: Cytoplasmic linker-associated proteins (CLASPs) form a conserved family of microtubule-associated proteins (MAPs) that maintain microtubules in a growing state by promoting rescue while suppressing catastrophe.1  CLASP function involves an ordered array of tumor overexpressed gene (TOG)…