The Veitia Lab recently published a new article in BioEssays : Dominant negative variants and cotranslational assembly of macromolecular complexes Abstract: Pathogenic variants occurring in protein-coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency. Dominant-negative (DN)…

The Palancade lab recently published a new article in FEBS Letters: Puzzling out nuclear pore complex assembly Abstract:  Nuclear pore complexes (NPCs) are sophisticated multiprotein assemblies embedded within the nuclear envelope and controlling the exchanges of molecules between the cytoplasm and the nucleus. In this review, we summarize the mechanisms by which these elaborate complexes are built…

The Dumont Lab recently published an article in Current Biology: An unconventional TOG domain is required for CLASP localization Abstract: Cytoplasmic linker-associated proteins (CLASPs) form a conserved family of microtubule-associated proteins (MAPs) that maintain microtubules in a growing state by promoting rescue while suppressing catastrophe.1  CLASP function involves an ordered array of tumor overexpressed gene (TOG)…

The Greenberg Lab recently contributed to the publication of a new article in Nature Structural & Molecular Biology: A genome-wide screen reveals new regulators of the 2-cell-like cell state Abstract: In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse ‘2-cell-like cells’ (2CLCs), which appear at…

The Pintard  lab rencently published in Science Advances: Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos Abstract: The nuclear envelope, which protects and organizes the genome, is dismantled during mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the parental pronuclei is spatially and temporally regulated during mitosis…

The Cadoret Lab recently published in International Journal of Molecular Sciences : Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Abstract: Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F pathway and induce…

The Minc Lab recently published a new article in Developmental Cell: Length limitation of astral microtubules orients cell divisions in murine intestinal crypts Abstract: Planar spindle orientation is critical for epithelial tissue organization and is generally instructed by the long cell-shape axis or cortical polarity domains. We introduced mouse intestinal organoids in order to study spindle…

The ProtéoSeine plateform contributed to the publication of a new article in Journal of Cellular and Molecular Medicine: Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice Abstract: Down syndrome is the most common chromosomal abnormality in humans. Patients with Down syndrome have hematologic disorders, including mild to moderate thrombocytopenia. In…

The Dumont lab recently published in Nature Communications: Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes Abstract: During cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend on interactions between spindle microtubules and kinetochores, and are pre-requisite for chromosome…

The Raote Lab contributed to the new review published in Disease Models & Mechanisms: CYLD in health and disease Abstract: CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important roles in immunity and cancer. Complete CYLD ablation, truncation and expression of alternate isoforms, including short CYLD, drive distinct phenotypes and offer insights into CYLD function in inflammation,…