The Dumont Lab published a new article in Current Biology : Regulation of outer kinetochore assembly during meiosis I and II by CENP-A and KNL-2/M18BP1 in C. elegans oocytes   Abstract: During cell division, chromosomes build kinetochores that attach to spindle microtubules. Kinetochores usually form at the centromeres, which contain CENP-A nucleosomes. The outer kinetochore, which is the core attachment…

The Pintard Lab contributed to a new article published in Nucleic Acids Research: Enhanced Golden Gate Assembly: evaluating overhang strength for improved ligation efficiency   Abstract: Molecular cloning, a routine yet essential technique, relies heavily on efficient ligation, which can be significantly improved using Golden Gate Assembly (GGA). A key component of GGA is the use of type IIS…

The Gazave Lab published a new article in Genome Biology and Evolution: Evolution of apoptotic signalling pathways within lophotrochozoans   Abstract: Apoptosis is the main form of regulated cell death in metazoans. Apoptotic pathways are well characterised in nematode, fly and mammals, leading to a vision of the conservation of apoptotic pathways in metazoans. However, we recently showed…

The Greenberg lab published a new article in Nucleic Acids Research : The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation   Abstract: During mammalian embryogenesis, both the 5-cytosine DNA methylation (5meC) landscape and three dimensional (3D) chromatin architecture are profoundly remodeled during a process known as ‘epigenetic reprogramming.’ An understudied aspect of epigenetic reprogramming…

The Grange/Geigl Lab contributed to the publication to a new in Annals of Rheumatic Diseases : SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase   Abstract: Objectives Inflammatory mediators such as interleukin 6 (IL-6) are known to activate catabolic responses in chondrocytes during osteoarthritis (OA). This study aimed to investigate the role of a downstream target…

The Romet-Lemonne / Jégou Lab  published a new Editorial in European Journal of Cell Biology : Editorial - In vitro reconstitution of cytoskeletal processes   Jégou A, Romet-Lemonne G. Editorial - In vitro reconstitution of cytoskeletal processes. Eur J Cell Biol. 2024 Sep;103(3):151443. doi: 10.1016/j.ejcb.2024.151443. Epub 2024 Jul 14. PMID: 39048475.

The Minc Lab published a nex article in Molecular Biology of the Cell : Mechanical strategies supporting growth and size diversity in Filamentous Fungi   Abstract: The stereotypical tip growth of filamentous fungi supports their lifestyles and functions. It relies on the polarized remodeling and expansion of a protective elastic cell wall (CW) driven by large cytoplasmic turgor…

The Dumont Lab published a new article in Nature Communication: Maternal inheritance of functional centrioles in two parthenogenetic nematodes   Abstract: Centrioles are the core constituent of centrosomes, microtubule-organizing centers involved in directing mitotic spindle assembly and chromosome segregation in animal cells. In sexually reproducing species, centrioles degenerate during oogenesis and female meiosis is usually acentrosomal. Centrioles are…

The Raote Lab contributed to the publication of a new article in Developmental Cell: Endoplasmic reticulum exit sites are segregated for secretion based on cargo size   Abstract: TANGO1, TANGO1-Short, and cTAGE5 form stable complexes at the endoplasmic reticulum exit sites (ERES) to preferably export bulky cargoes. Their C-terminal proline-rich domain (PRD) binds Sec23A and affects COPII assembly. The PRD in TANGO1-Short…