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Romet-Lemonne/Jégou Lab – Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

The Romet-Lemonne/Jégou Lab contributed to the publication of a new article in Nature structural & molecular biology: Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament   Résumé: Regulation of the assembly and turnover of branched actin filament networks nucleated by the Arp2/3 complex is essential during many cellular processes, including cell migration and…

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Romet-Lemonne/Jégou Lab – Regeneration of actin filament branches from the same Arp2/3 complex

The Romet-Lemonne/Jégou Lab published a new article in Science Advances: Regeneration of actin filament branches from the same Arp2/3 complex Abstract: Branched actin filaments are found in many key cellular structures. Branches are nucleated by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to the side of preexisting “mother” filaments. Over time, branches dissociate…

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Symposium on cortical and spinal organoids

Symposium on cortical and spinal organoids - January 29th, 2024 The symposium on cerebral and spinal organoids is organised by the enSCORE platform of the Université Paris Cité (Labex "Who am I?", Institut Jacques Monod, Epigénétique et Destin Cellulaire) and the DIM C-BRAINS. It focuses on innovative 3D models of nervous system development in organoids derived from…

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Call for group leaders

 The Institut Jacques Monod (IJM), a leading center for fundamental interdisciplinary research in biology, is seeking to appoint at least two new group leaders.   The Institute comprises 28 international research groups working in the fields of biophysics, cell and developmental biology, evolution and genome biology. The IJM is affiliated with the Centre National de la Recherche…

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IJM Seminar – Anaïs Bardet – 23/02/2024

Invited by the Gazave, Anaïs Bardet (CNRS, IGBMC, Strasbourg), will present an IJM seminar on the theme: Transcription factor sensitivity to DNA methylation   Abstract: Multicellular organisms establish and maintain different transcriptional states in disparate cell types through complex and specific regulation of gene expression. This regulation is mediated by the cooperative binding of transcription factors to regulatory…

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IJM Seminar – Arnaud Echard – 09/02/2024

Invited by the Pintard, Arnaud Echard (Institut Pasteur) will present an IJM seminar on the theme: Cell division: the final cut   Abstract: We are interested in one of the most fundamental questions in biology: How a cell divides into two daughter cells. We particularly focus on cytokinesis, the last step of cell division leading to the physical…

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IJM Seminar – Alexander Palazzo – 02/02/2024

Invited by the Palancade lab, Alexander Palazzo (Biochemistry Department, University of Toronto / Laboratoire Interdisciplinaire des Science Numérique, Université Paris-Saclay) will présent an IJM seminar on the theme: How mRNA nuclear export allows you to live with a genome filled with junk DNA   Abstract: In eukaryotes, the division of the cellular space into nucleoplasm and cytoplasm promotes…

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IJM Seminar – Mounia Lagha – 26/01/2024

Invited by the Palancade, Mounia Lagha (Institut de Génétique Moléculaire de Montpellier) will present the IJm seminar: Lighting up the central dogma to dissect how sharp developmental patterns are established   "A fundamental question in biology is how cellular processes are so reproducible despite the inherent variations in the chemical reactions governing them. During development of a…

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