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IJM Seminar – Olivier Tenaillon – 14/10/2022

News3 October 2022
Invited by Virginie Courtier, Olivier Tenaillon (Inserm, Université Paris Cité) will give on October 14th a seminar entitled : "Molecular determinants of bacterial adaptation in vitro, in vivo, in infectio. " Research interests     With the rise of antibiotic resistance and the emergence of new forms of virulence, it has become clear that microbial evolution is…

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Wassmann Lab – Protocol to measure cleavage efficiency of the meiotic cohesin subunit Rec8 by separase in mouse oocytes using a biosensor

Home publis, News29 September 2022
The Wassmann Team has just published a new paper in Star Protocols! Protocol to measure cleavage efficiency of the meiotic cohesin subunit Rec8 by separase in mouse oocytes using a biosensor   Summary Here, we describe a biosensor to assess meiotic cohesin subunit Rec8 cleavage in mouse oocytes. We detail oocyte collection and microinjection of the mRNA…

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Ladoux/Mège Lab – The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces

Home publis, News16 September 2022
The Ladoux/Mège Team has just published a new paper in Science Advances: The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces   Abstract Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship with substrate curvatures are intimately linked to spontaneous…

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Plessis Lab – High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

Home publis, News12 September 2022
The Plessis Lab has just published a new paper in eLife! High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened Abstract The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures.…

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IJM Seminar – Pierre Nassoy – 07/10/2022

News2 September 2022
Invited by Benoit Ladoux, Pierre Nassoy (UMR 5298 CNRS, Laboratoire de Photonique, Numérique et Nanosciences) will give on October 7th a seminar entitled: Self-assembly and mechanosensing in bloody, nervous, fat or tumoral organoids   BIOF LAB : BIOIMAGING & OPTOFLUIDICS LABORATORY Our lab has developed a microfluidics-assisted technique, the Cellular Capsule Technology (CCT) that enables to…

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IJM Seminar – Morgan Delarue – 30/09/2022

News2 September 2022
Invited by Nicolas Minc, Morgan Delarue (Team MILE, LAAS-CNRS) will give on September 30th a seminar entitled: Cell growth under mechanical pressure   Team MILE, LAAS-CNRS Our research focuses on compressive mechanicalstress: What happens when cells are squished? What are the biological and physical determinants of the response to compression? Is there an evolutionarily conserved response? How does…

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Léon Lab – 2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity

Home publis, News1 September 2022
A new paper just published by Léon Lab in PLOS Genetics! 2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity   Abstract 2-deoxyglucose is a glucose analog that impacts many aspects of cellular physiology. After its uptake and its phosphorylation into 2-deoxyglucose-6-phosphate (2DG6P), it interferes with several metabolic pathways including glycolysis and…

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