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Duharcourt Lab – Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements

Home publis21 April 2022
A new paper published by Duharcourt Team in Developmental Cell! Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements   Summary Polycomb repressive complex 2 (PRC2) maintains transcriptionally silent genes in a repressed state via deposition of histone H3K27-trimethyl (me3) marks. PRC2 has also been implicated in silencing transposable elements (TEs), yet how PRC2…

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Sandra Duharcourt, CNRS Silver Medal

News20 April 2022
Sandra Duharcourt, Director of Research at the CNRS and head of the "Epigenetic Regulation of Genome Organization" team at the Institut Jacques Monod (CNRS / Université Paris Cité), is the recipient of the 2022 CNRS Silver Medal. The CNRS Silver Medal is awarded to researchers for the originality, quality and importance of their work, recognised at…

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Konstantinides Lab: A complete temporal transcription factor series in the fly visual system

Home publis, News7 April 2022
A new paper just published in Nature by Nikos Konstantinides! Congratulations to all the authors   A complete temporal transcription factor series in the fly visual system   Abstract The brain consists of thousands of neuronal types that are generated by stem cells producing different neuronal types as they age. In Drosophila, this temporal patterning is driven by the successive expression…

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Courtier Lab: Non-visual cues and indirect strategies that enable discrimination of asymmetric mates

Home publis, News6 April 2022
Congratulations to Roshan Kumar Vijendravarma (Courtier Lab) for this new article published with Pierre Leopold (Institut Curie) in Ecology and Evolution: Non-visual cues and indirect strategies that enable discrimination of asymmetric mates   Abstract The postulates of developmental instability–sexual selection hypothesis is intensely debated among evolutionary biologists, wherein despite a large amount of empirical data, evidence for…

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Duharcourt Lab: GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium

Home publis, News5 April 2022
A new paper just published by Duharcourt Team in Genome Research! GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium   Abstract Eukaryotic genes are interrupted by introns that must be accurately spliced from mRNA precursors. With an average length of 25 nt, the more than 90,000 introns of Paramecium tetraurelia stand among the…

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Monod-Diderot Conference – Claude Desplan – 19/04/2021

News4 April 2022
The Monod-Diderot Lectures receive Claude Desplan (Silver Professor of Biology and Neuroscience, NYU Department of Biology, New York University) on 19 April 2022 at 11:45 am in the Buffon amphitheatre. He will speak on the theme : Spatial and temporal cues for the generation of neuronal diversity     Claude Desplan is a Silver Professor of Biology and Neuro-science…

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Azimzadeh Lab: Evolutionary conservation of centriole rotational asymmetry in the human centrosome

Home publis, News30 March 2022
The Azimzadeh Lab has just published a new study in elife : Evolutionary conservation of centriole rotational asymmetry in the human centrosome   Abstract Centrioles are formed by microtubule triplets in a nine-fold symmetric arrangement. In flagellated protists and in animal multiciliated cells, accessory structures tethered to specific triplets render the centrioles rotationally asymmetric, a property that…

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Pintard Lab: Cortical microtubule pulling forces contribute to the union of the parental genomes in the Caenorhabditis elegans zygote

Home publis, News25 March 2022
The Pintard Team has just published a new paper in eLife : Cortical microtubule pulling forces contribute to the union of the parental genomes in the Caenorhabditis elegans zygote   Abstract Previously, we reported that the Polo-like kinase PLK-1 phosphorylates the single Caenorhabditis elegans lamin (LMN-1) to trigger lamina depolymerization during mitosis. We showed that this event is required to form…

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Minc Lab: Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning

Home publis, News20 March 2022
The Minc Team has just published a new paper in PNAS : Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning   Abstract Cells are filled with macromolecules and polymer networks that set scale-dependent viscous and elastic properties to the cytoplasm. Although the role of these parameters in molecular diffusion, reaction kinetics, and cellular biochemistry is being increasingly…

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