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LSC Lecture – Lera Boroditsky – 19/06/2024

Life, Structure and Cognition 2024 - A multitude of times   As part of the “Life Structure and Cognition 2024 : A multitude of times" meeting,  Lera Boroditsky (University of California, San Diego), Professor of sciences cognition will present the conference « How languages and cultures construct time » on June, 19th at 6pm in Buffon…

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IJM Seminar – Matthias Peter – 18/06/2024

On June, Tuesday 18th, the Labex WHO AM I? invites Professor Matthias Peter (Institute of Biochemistry, ETH Zurich) to present an IJM Seminar on the theme: Ubiquitin tails   Abstract: We are interested in the function of E3-ubiquitin ligases orchestrating diverse cellular processes. For many years, we characterized the regulation and function of Cullin-RING E3 ligases (CRLs), which…

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IJM Seminar – Olivia de Roure – 14/06/2024

Invited by the Ladoux/Mège, Olivia Du Roure (Laboratoire PMMH ESPCI Paris PSL) will present an Institut Jacques Monod Seminar on the theme: Dynamics and mechanics of the cortex of living cells Abstract: The cell cortex is a contractile actin meshwork located below the plasma membrane, which determines cell shape and is instrumental for cell mechanics, migration and…

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IJM Seminar – Nick Irwin – 7/06/2024

Invited by the Duharcourt lab, Nick Irwin (Gregor Mendel Institute, Vienna BioCenter) will present an Institut Jacques Monod Seminar on the theme: Self-assembling viral histones unravel early nucleosome evolution   Abstract: The nucleosome is a defining feature of eukarytoes that plays a central role in the coordination and regulation of the genome. Accordingly, understanding the origin of the…

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Microphysio24: From organoids to organs-on-chips

Microphysio24: From organoids to organs-on-chips The 2nd edition of the MicroPhysio conference on "Micro-physiological models: From organoids to organs-on-chip"  will take place at the CNRS center in Cargèse (www.iesc.univ-corse.fr) from September 23rd to September 27th, 2024. It is becoming increasingly clear that even the best in vivo models such as genetically-modified mouse models or orthotopic patient-derived xenografts cannot recapitulate the full complexity of human…

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ImagoSeine – CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT

The ImagoSeine platform contributed to the publication of a new article in Circulation: CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT   Abstract: BACKGROUND: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions…

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Dumont Lab – Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane

The Dumont Lab contributed to the publication of a new article in Molecular Biology of Cell: Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane   Abstract: Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of an…

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Ribes Lab – Non-Mammalian Models for Understanding Neurological Defects in RASopathies

The Ribes Lab contributed to the publication of a review in Biomedicines: Non-Mammalian Models for Understanding Neurological Defects in RASopathies   Abstract: RASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders. Afflicting approximately one in a thousand newborns, RASopathies manifest…

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Jackson/Verbavatz Lab – Staying on track – Keeping things running in a high-end scientific imaging core facility

The  Jackson/Verbavatz Lab contributed to the publication of a themed issue article: Staying on track – Keeping things running in a high-end scientific imaging core facility   Abstract: Modern life science research is a collaborative effort. Few research groups can single-handedly support the necessary equipment, expertise and personnel needed for the ever-expanding portfolio of technologies that are required…

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Raote Lab – TANGO1 inhibitors reduce collagen secretion and limit tissue scarring

The Raote Lab published a new article in Nature communications: TANGO1 inhibitors reduce collagen secretion and limit tissue scarring   Abstract: Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies are lacking. A promising approach would be…

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