The Raote Lab published a new article in Nature communications: TANGO1 inhibitors reduce collagen secretion and limit tissue scarring   Abstract: Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies are lacking. A promising approach would be…

The Duharcourt Lab published a new review in WIREs RNA : Small-RNA-guided histone modifications and somatic genome elimination in ciliates   Abstract: Transposable elements and other repeats are repressed by small-RNA-guided histone modifications in fungi, plants and animals. The specificity of silencing is achieved through base-pairing of small RNAs corresponding to the these genomic loci to nascent noncoding…

The Conduit Lab published a new article in Journal of Cell Science: γ-TuRCs and Augmin are required for the development of highly branched dendritic arbors in Drosophila   Abstract: Microtubules are nucleated by γ-tubulin ring complexes (γ-TuRCs) and are essential for neuronal development. Nevertheless, γ-TuRC depletion has been reported to perturb only higher-order branching in elaborated Drosophila larval class IV…

The Palancade team contributed to the editorial published in the special edition of Yeast: Gene transcription in yeasts: From molecules to integrated processes   The cover image was created by Benoît Palancade and Coralie Goncalves.  

The Palancade Lab contributed to the publication of a new article in Nature communications : Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation Abstract: Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences…

The Greenberg Lab published a new article in Nature structural & molecular biology: The impact of DNA methylation on CTCF-mediated 3D genome organization Abstract: Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although the role of DNA methylation at gene promoters and repetitive elements has been extensively studied, the function of DNA methylation…

The ProtéoSeine et ImagoSeine plateforms contributed to the publication of an article in Nature communications: Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy Abstract Intracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp. have evolved sophisticated strategies…