L'équipe Cadoret a récemment publié un article dans International Journal of Molecular Sciences : Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Résumé : Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F…

L'équipe Minc a récemment publié un nouvel article dans Developmental Cell : Length limitation of astral microtubules orients cell divisions in murine intestinal crypts Résumé : Planar spindle orientation is critical for epithelial tissue organization and is generally instructed by the long cell-shape axis or cortical polarity domains. We introduced mouse intestinal organoids in order to…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans  Journal of Cellular and Molecular Medicine : Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice Résumé : Down syndrome is the most common chromosomal abnormality in humans. Patients with Down syndrome have hematologic disorders, including mild to moderate…

L'équipe Dumont a récemment publié dans Nature Communications : Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes Résumé : During cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend on interactions between spindle microtubules and kinetochores, and are pre-requisite…

L'équipe Raote a contribué à la publication d'une nouvelle revue dans Disease Models & Mechanisms : CYLD in health and disease Résumé : CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important roles in immunity and cancer. Complete CYLD ablation, truncation and expression of alternate isoforms, including short CYLD, drive distinct phenotypes and offer insights into CYLD…

L'équipe Gazave a récemment publié dans BMC Biology : The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes   Résumé : Background Explaining the emergence of the hallmarks of bilaterians is a central focus of evolutionary developmental biology—evodevo—and evolutionary genomics. For this purpose, we must both expand and also refine our knowledge of non-bilaterian…

L'équipe Guichet a récemment publié un article dans Development : Kinesin-1 promotes centrosome clustering and nuclear migration in the Drosophila oocyte Résumé : Microtubules and their associated motors are important players in nucleus positioning. Although nuclear migration in Drosophila oocytes is controlled by microtubules, a precise role for microtubule-associated molecular motors in nuclear migration has yet to be reported.…

L'équipe Jackson/Verbavatz a récemment publié dans Journal of Biomedical Optics : Enhanced neuroimaging with a calcium sensor in ex-vivo Drosophila melanogaster brains using closed-loop adaptive optics light-sheet fluorescence microscopy   Résumé : Significance Adaptive optics (AO) has been implemented on several microscopy setups and has proven its ability to increase both signal and resolution. However, reported configurations are not suited…

L'équipe Romet/Lemonne/Jégou a récemment publié dans Physical review : Models of vimentin organization under actin-driven transport Résumé : Intermediate filaments form an essential structural network, spread throughout the cytoplasm, and play a key role in cell mechanics, intracellular organization, and molecular signaling. The maintenance of the network and its adaptation to the cell's dynamic behavior relies on…

L'équipe Greenberg a récemment publié dans Development : Non-canonical imprinting in the spotlight   Résumé : Classical genomic imprints are regulated by parent-specific DNA methylation levels inherited from the gametes in mammals. Imprints control gene expression in a parent-of-origin manner and are essential for development. A distinct class of so-called ‘non-canonical’ imprints was recently discovered; these are…