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Romet-Lemonne / Jégou Lab: Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles

Actualités, Les dernières publications24 mai 2022
Félicitations à l'équipe Romet-Lemonne / Jégou pour ce nouvel article publié dans JoVE: Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles Abstract In order to decipher the complex molecular mechanisms that regulate the assembly and disassembly of actin filaments, it is a great asset to monitor individual reactions…

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Ribes Lab – Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs

Actualités, Les dernières publications24 mai 2022
Félicitations à l'équipe Ribes pour ce nouvel article publié dans PLOS Genetics!   Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs   Abstract The hallmarks of the alveolar subclass of rhabdomyosarcoma are chromosomal translocations that generate chimeric PAX3-FOXO1 or PAX7-FOXO1 transcription factors. Overexpression of either PAX-FOXO1s results in related cell transformation in animal models. Yet, in patients…

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Libri Lab: A Modified Cross-Linking Analysis of cDNAs (CRAC) Protocol for Detecting RNA–Protein Interactions and Transcription at Single-Nucleotide Resolution

Les dernières publications9 mai 2022
Vient de paraitre dans Yeast Functional Genomics  pp 35-55 A Modified Cross-Linking Analysis of cDNAs (CRAC) Protocol for Detecting RNA–Protein Interactions and Transcription at Single-Nucleotide Resolution by: Drice Challal Jessie Colin Tommaso Villa Domenico Libri   Abstract Detecting protein–RNA interactions in vivo is essential for deciphering many important cellular pathways. Several…

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Camadro Lab / ProtéoSeine: Quantitative Proteomics in Yeast : From bSLIM and Proteome Discoverer Outputs to Graphical Assessment of the Significance of Protein Quantification Scores

Les dernières publications9 mai 2022
Vient de paraître dans Yeast Functional Genomics  pp 275-292   Quantitative Proteomics in Yeast : From bSLIM and Proteome Discoverer Outputs to Graphical Assessment of the Significance of Protein Quantification Scores By Nicolas Sénécaut Pierre Poulain Laurent Lignières Samuel Terrier Véronique Legros Guillaume Chevreux Gaëlle Lelandais Jean-Michel Camadro

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Pintard Lab: The kiss of life: Aurora A embraces the phosphate of its cofactor Bora to trigger mitotic entry

Les dernières publications9 mai 2022
Un nouvel article publié dans médecine/sciences par l'équipe Pintard : The kiss of life: Aurora A embraces the phosphate of its cofactor Bora to trigger mitotic entry   La plupart des organismes vivants pluricellulaires sont constitués d’un grand nombre de cellules très différentes. À l’exception des gamètes, qui sont le produit d’une division cellulaire particulière (méiose), toutes…

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Duharcourt Lab – Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements

Les dernières publications21 avril 2022
Un nouvel article publié par l’équipe Duharcourt dans Developmental Cell! Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements   Summary Polycomb repressive complex 2 (PRC2) maintains transcriptionally silent genes in a repressed state via deposition of histone H3K27-trimethyl (me3) marks. PRC2 has also been implicated in silencing transposable elements (TEs), yet how PRC2 is…

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Konstantinides Lab: A complete temporal transcription factor series in the fly visual system

Actualités, Les dernières publications7 avril 2022
Un nouvel article publié dans Nature par Nikos Konstantinides! Félicitations à tous les auteurs !   A complete temporal transcription factor series in the fly visual system   Abstract The brain consists of thousands of neuronal types that are generated by stem cells producing different neuronal types as they age. In Drosophila, this temporal patterning is driven by the successive expression…

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Courtier Lab: Non-visual cues and indirect strategies that enable discrimination of asymmetric mates

Actualités, Les dernières publications6 avril 2022
Félicitations à Roshan Kumar Vijendravarma (Courtier Lab) pour ce nouvel article publié avec Pierre Leopold (Institut Curie) dans Ecology and Evolution: Non-visual cues and indirect strategies that enable discrimination of asymmetric mates   Abstract The postulates of developmental instability–sexual selection hypothesis is intensely debated among evolutionary biologists, wherein despite a large amount of empirical data, evidence for…

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Duharcourt Lab: GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium

Actualités, Les dernières publications5 avril 2022
Un nouvel article publié par l'équipe Duharcourt dans Genome Research! GC content, but not nucleosome positioning, directly contributes to intron splicing efficiency in Paramecium   Abstract Eukaryotic genes are interrupted by introns that must be accurately spliced from mRNA precursors. With an average length of 25 nt, the more than 90,000 introns of Paramecium tetraurelia stand among the shortest…

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Azimzadeh Lab: Evolutionary conservation of centriole rotational asymmetry in the human centrosome

Actualités, Les dernières publications30 mars 2022
L'équipe Azimzadeh a publié le 23 mars dernier un nouvel article dans elife : Evolutionary conservation of centriole rotational asymmetry in the human centrosome   Les centrioles sont des structures de petite taille impliquées dans des processus essentiels tels que la division, la migration et la communication cellulaire. Grâce à une technique récente de microscopie super-résolutive, des…

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