L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans The European Physical Journal E : Probing protein–protein interactions with drag flow: a case study of F-actin and tropomyosin Résumé : Tropomyosins are central regulators of the actin cytoskeleton, controlling the binding and activity of the other actin binding proteins. The interaction between tropomyosin and actin is…

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nature Communications : UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells   Résumé : In mammals, primordial germ cells (PGCs) undergo global erasure of DNA methylation with delayed demethylation of germline genes and selective retention of DNA methylation at evolutionarily young retrotransposons. However, the molecular mechanisms…

L'équipe Wassmann a publié un nouvel article dans EMBO : Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II Abstract : The meiotic segregation pattern to generate haploid gametes is mediated by step-wise cohesion removal by separase, first from chromosome arms in meiosis I, and then from the pericentromere in meiosis II. In…

L'équipe Minc a contribué à la publication d'un nouvel article dans Biophysical Journal : Inferring diffusion, reaction, and exchange parameters from imperfect FRAP Résumé : Fluorescence recovery after photobleaching (FRAP) is broadly used to investigate the dynamics of molecules in cells and tissues, notably to quantify diffusion coefficients. FRAP is based on the spatiotemporal imaging of fluorescent…

L'équipe Ribes/Nedelec a contribué à la publication d'un nouvel article dans Science Advances : GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration   Résumé : The saltatory migration of neurons is essential for brain formation. Whether mechanical stimuli regulate this process is unknown. Here, we show that the primary cilium acts as a mechanical sensor through…

L'équipe Wassmann a contribué à l'ouvrage Mammalian Oocyte Development : “JessTM Simple WesternTM”: A New Technology to Assess Protein Abundance in Mouse Oocytes Résumé : Traditional Western blot technology coupled with two-dimensional  SDS-PAGE has been used for decades to detect specific proteins in extracts. Here we describe an automated Western technology based on protein separation by capillary assay.…

L'équipe Jackson/Verbavatz a contribué à la publication d'un nouvel article dans Traffic : Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases Résumé : Arf and Rab family small GTPases and their regulators, GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), play a central role in membrane trafficking. In this study, we…

L'équipe Gazave a contribué à la publication d'un nouvel article dans BMC Genomics : A genome resource for the marine annelid Platynereis spp Résumé : The marine annelid Platynereis dumerilii is a model organism used in many research areas including evolution and development, neurobiology, ecology and regeneration. Here we present the genomes of P. dumerilii (laboratory culture…

L'équipe Veitia a publié un nouvel article dans Journal of inherited metabolic disease : Gene Dosage Sensitivity and Human Genetic Diseases Résumé : Here we review the historical background and contemporary insights into genetic dominance, focusing on haploinsufficiency (HI), that is, when the function of only one allele of a gene is not enough to ensure a…

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans médecine/science : La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires Lemichez E, Morel C, Leduc C, Bassereau P. La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires [Caveolin-1 stiffens the plasma membrane and limits transcellular tunnel expansion]. Med…