Skip to content Skip to footer

Dumont Lab – Maternal inheritance of functional centrioles in two parthenogenetic nematodes

L'équipe Dumont a publié un nouvel article dans Nature Communication : Maternal inheritance of functional centrioles in two parthenogenetic nematodes   Résumé : Centrioles are the core constituent of centrosomes, microtubule-organizing centers involved in directing mitotic spindle assembly and chromosome segregation in animal cells. In sexually reproducing species, centrioles degenerate during oogenesis and female meiosis is usually acentrosomal.…

Read More

Raote Lab – Endoplasmic reticulum exit sites are segregated for secretion based on cargo size

L'équipe Raote a contribué à la publication d'un nouvel article dans Developmental Cell : Endoplasmic reticulum exit sites are segregated for secretion based on cargo size   Résumé : TANGO1, TANGO1-Short, and cTAGE5 form stable complexes at the endoplasmic reticulum exit sites (ERES) to preferably export bulky cargoes. Their C-terminal proline-rich domain (PRD) binds Sec23A and affects COPII assembly. The PRD in…

Read More

Conduit Lab – Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation

L'équipe Conduit a publié une nouvelle revue dans Nature Structural & Molecular Biology : Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation   Résumé : Microtubules within cells often have 13 protofilaments but are nucleated by multi-protein y-TuRCs complexes that display 14 γ-tubulin molecules. High-resolution cryo-EM structures of γ-TuRCs after nucleation show that these γ-TuRCs ‘close’…

Read More

Gazave Lab – Variations in cell plasticity and proliferation underlie distinct modes of regeneration along the antero-posterior axis in the annelid Platynereis

L'équipe Gazave a publié un nouvel article dans Development : Variations in cell plasticity and proliferation underlie distinct modes of regeneration along the antero-posterior axis in the annelid Platynereis   Résumé : The capacity to regenerate lost tissues varies significantly among animals. Some phyla, such as the annelids, display substantial regenerating abilities, although little is known about…

Read More

Konstantinides Lab – Neuronal Circuit Evolution: From Development to Structure and Adaptive Significance

L'équipe Konstantinides a publié un nouvel article dans CSH Perspectives : Neuronal Circuit Evolution: From Development to Structure and Adaptive Significance   Résumé : Neuronal circuits represent the functional units of the brain. Understanding how the circuits are generated to perform computations will help us understand how the brain functions. Nevertheless, neuronal circuits are not engineered, but have…

Read More

Grange/Geigl Lab – L’arrivée de l’ascendance des steppes dans le nord de la France observée en temps réel explique la constitution du génome européen

L'équipe Grange/Geigl a publié un nouvel article dans Science Advances : L’arrivée de l’ascendance des steppes dans le nord de la France observée en temps réel explique la constitution du génome européen   La dernière vague migratoire majeure ayant façonné le génome européen était celle des populations des steppes au nord de la Mer Noire il y…

Read More

IJM – Direct observation of fluorescent proteins in gels: a rapid, cost-efficient and quantitative alternative to immunoblotting

Des chercheurs de l'Institut Jacques Monod  ont publié une étude collaborative ( preprint) sur les conditions d'utilisation de divers GFP et RFP pour la détection directe de la fluorescence dans les gels : Direct observation of fluorescent proteins in gels: a rapid, cost-efficient and quantitative alternative to immunoblotting   Résumé : The discovery of Green Fluorescent Protein (GFP)…

Read More

ImagoSeine – Altered X-chromosome inactivation predisposes to autoimmunity

La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Science Advances : Altered X-chromosome inactivation predisposes to autoimmunity   Résumé : In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases, while females are more susceptible to systemic autoimmunity. X-chromosome inactivation (XCI), the epigenetic mechanism ensuring the…

Read More

ImagoSeine – CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT

La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Circulation : CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT   Résumé : BACKGROUND: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug…

Read More

Dumont Lab – Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane

L'équipe Dumont a contribué à la publication d'un nouvel article dans Molecular Biology of Cell : Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane   Résumé : Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of…

Read More