L'équipe Dumont a publié un nouvel article dans Nature Communication :
Maternal inheritance of functional centrioles in two parthenogenetic nematodes
Résumé :
Centrioles are the core constituent of centrosomes, microtubule-organizing centers involved in directing mitotic spindle assembly and chromosome segregation in animal cells. In sexually reproducing species, centrioles degenerate during oogenesis and female meiosis is usually acentrosomal.…
L'équipe Raote a contribué à la publication d'un nouvel article dans Developmental Cell :
Endoplasmic reticulum exit sites are segregated for secretion based on cargo size
Résumé :
TANGO1, TANGO1-Short, and cTAGE5 form stable complexes at the endoplasmic reticulum exit sites (ERES) to preferably export bulky cargoes. Their C-terminal proline-rich domain (PRD) binds Sec23A and affects COPII assembly. The PRD in…
L'équipe Conduit a publié une nouvelle revue dans Nature Structural & Molecular Biology :
Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation
Résumé :
Microtubules within cells often have 13 protofilaments but are nucleated by multi-protein y-TuRCs complexes that display 14 γ-tubulin molecules. High-resolution cryo-EM structures of γ-TuRCs after nucleation show that these γ-TuRCs ‘close’…
L'équipe Gazave a publié un nouvel article dans Development :
Variations in cell plasticity and proliferation underlie distinct modes of regeneration along the antero-posterior axis in the annelid Platynereis
Résumé :
The capacity to regenerate lost tissues varies significantly among animals. Some phyla, such as the annelids, display substantial regenerating abilities, although little is known about…
L'équipe Konstantinides a publié un nouvel article dans CSH Perspectives :
Neuronal Circuit Evolution: From Development to Structure and Adaptive Significance
Résumé :
Neuronal circuits represent the functional units of the brain. Understanding how the circuits are generated to perform computations will help us understand how the brain functions. Nevertheless, neuronal circuits are not engineered, but have…
L'équipe Grange/Geigl a publié un nouvel article dans Science Advances :
L’arrivée de l’ascendance des steppes dans le nord de la France observée en temps réel explique la constitution du génome européen
La dernière vague migratoire majeure ayant façonné le génome européen était celle des populations des steppes au nord de la Mer Noire il y…
Des chercheurs de l'Institut Jacques Monod ont publié une étude collaborative ( preprint) sur les conditions d'utilisation de divers GFP et RFP pour la détection directe de la fluorescence dans les gels :
Direct observation of fluorescent proteins in gels: a rapid, cost-efficient and quantitative alternative to immunoblotting
Résumé :
The discovery of Green Fluorescent Protein (GFP)…
La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Science Advances :
Altered X-chromosome inactivation predisposes to autoimmunity
Résumé :
In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases, while females are more susceptible to systemic autoimmunity. X-chromosome inactivation (XCI), the epigenetic mechanism ensuring the…
La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Circulation :
CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT
Résumé :
BACKGROUND:
Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug…
L'équipe Dumont a contribué à la publication d'un nouvel article dans Molecular Biology of Cell :
Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane
Résumé :
Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of…