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JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development

Les dernières publications27 février 2024
Un nouvel article a été publié dans Nature Communications : JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development Cette étude est le fruit d'une collaboration entre des scientifiques l’Institut de biologie intégrative de la cellule (université Paris-Saclay) et de l'Institut Jacques Monod (Konstantinides Lab, Minc Lab, Guichet Lab).   Résumé : The number of…

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Pintard Lab – Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans

Actualités, Les dernières publications13 février 2024
L'équipe Pintard a publié un nouvel article dans Journal of Cell Biology : Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans   Résumé : Microtubule-severing enzymes (MSEs), such as Katanin, Spastin, and Fidgetin play essential roles in cell division and neurogenesis. They damage the microtubule (MT) lattice, which can either destroy or amplify…

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Courtier Lab – Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences

Actualités, Les dernières publications13 février 2024
L'équipe Courtier a récemment publié un nouvel article dans BMC Ecology and Evolution : Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences Résumé : Background During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood.…

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Wassmann Lab – Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast

Actualités, Les dernières publications13 février 2024
L'équipe Wassmann a publié un nouvel article dans EMBO : Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast   Résumé : Exit from mitosis is brought about by dramatic changes in the phosphoproteome landscape. A drop in Cyclin-dependent kinase (Cdk) activity, the master regulatory kinase, and activation of counteracting phosphatases such as Cdc14…

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Romet-Lemonne/Jégou Lab – Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

Actualités, Les dernières publications29 janvier 2024
L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature structural & molecular biology : Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament   Résumé : Regulation of the assembly and turnover of branched actin filament networks nucleated by the Arp2/3 complex is essential during many cellular processes, including cell migration…

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Guichet Lab – The Importance of the Position of the Nucleus in Drosophila Oocyte Development

Actualités, Les dernières publications29 janvier 2024
L'équipe Guichet a publié un nouvel article dans Cells : The Importance of the Position of the Nucleus in Drosophila  Oocyte Development Résumé : Oogenesis is a developmental process leading to the formation of an oocyte, a haploid gamete, which upon fertilisation and sperm entry allows the male and the female pronuclei to fuse and give rise to…

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Romet-Lemonne/Jégou Lab – Regeneration of actin filament branches from the same Arp2/3 complex

Actualités, Les dernières publications29 janvier 2024
L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans Science Advances : Regeneration of actin filament branches from the same Arp2/3 complex Résumé : Branched actin filaments are found in many key cellular structures. Branches are nucleated by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to the side of preexisting “mother” filaments. Over time,…

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Palancade Lab – On the edge: how nuclear pore complexes rule genome stability

Actualités, Les dernières publications18 janvier 2024
L'équipe Palancade a publié une nouvelle review dans Current Opinion in Genetics & Development : On the edge: how nuclear pore complexes rule genome stability   Résumé : Nuclear organization has emerged as a critical layer in the coordination of DNA repair activities. Distinct types of DNA lesions have notably been shown to relocate at the vicinity…

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Greenberg lab – DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation

Actualités, Les dernières publications5 janvier 2024
L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nature Structural & Molecular biology : DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation   Résumé : As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation levels. During this transition, the…

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Camadro Lab / ProtéoSeine – Multiomic analysis in fibroblasts of patients with inborn errors of cobalamin metabolism reveals concordance with clinical and metabolic variability

Actualités, Les dernières publications5 janvier 2024
L'équipe Camadro et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans eBioMedicine : Multiomic analysis in fibroblasts of patients with inborn errors of cobalamin metabolism reveals concordance with clinical and metabolic variability   Résumé : Background The high variability in clinical and metabolic presentations of inborn errors of cobalamin (cbl) metabolism (IECM), such as the cblC/epicblC types…

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