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Sélection de Nikos Konstantinides au sein du réseau d’excellence de la Fédération des Sociétés Européennes de Neurosciences-Kavli

L’Institut Jacques Monod est très fier de vous annoncer la sélection et l’intégration de Nikos Konstantinides au sein du réseau d’excellence de la Fédération des Sociétés Européennes de Neurosciences-Kavli (The Federation of European Neuroscience Societies-Kavli Network of Excellence). Nous lui adressons toutes nos félicitations ! Le réseau d’excellence FENS-Kavli regroupe des chercheurs en neuroscience indépendants et en…

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Greenberg Lab – A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nucleic Acids Research : A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation   Résumé :  Epigenetic mechanisms are essential to establish and safeguard cellular identities in mammals. They dynamically regulate the expression of genes, transposable elements and higher-order chromatin structures.…

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Prioleau Lab – Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair

L'équipe Prioleau a contribué à la publication d'un nouvel article dans Nature communications : Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair Résumé : Histone post-translational modifications promote a chromatin environment that controls transcription, DNA replication and repair, but surprisingly few phosphorylations have been documented. We report the discovery of histone H3 serine-57…

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Soutenance de thèse – Olivia Charmant

Olivia Charmant (équipe Duharcourt) va présenter sa soutenance de thèse intitulée "Elimination programmée d'ADN chez Paramecium tetraurelia : caractérisation de protéines contrôlant la dynamique des petits ARN". La soutenance aura lieu le jeudi 21 septembre à 14h, dans la salle François Jacob de l'Institut Jacques Monod.

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Séminaire IJM – Alexander Woglar – 19/09/2023

Invité par Julien Dumont, Alexander Woglar (ETH Zurich) présentera un séminaire IJM sur le thème : Deciphering the dynamic molecular architecture of centrioles and meiotic chromosomes "Uncovering the architecture of complex, multi-protein containing macromolecular assemblies such as chromosomes or centrioles is key to understand the mechanism of their biogenesis and modes of function. To answerer open…

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Séminaire IJM – Peter Sarkies – 15/09/2023

Invité par Sandra Duharcourt, Peter Sarkies (Department of Biochemistry, University of Oxford) donnera un séminaire IJM sur le thème : Using evolution to understand epigenetic mechanisms   Epigenetics and Evolution Epigenetics allows different types of cells in the body to turn different sets of genes on or off without changing the underlying DNA sequence.  As a result, epigenetics…

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Palancade Lab – Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import

L'équipe Palancade a contribué à la publication d'un nouvel article dans Plos Genetics : Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import Résumé : N-terminal ends of polypeptides are critical for the selective co-translational recruitment of N-terminal modification enzymes. However, it is unknown whether specific N-terminal signatures differentially regulate protein fate…

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Prioleau Lab – Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates

L'équipe Prioleau a récemment publié un nouvel article dans Nature Communications : Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates Résumé : Replication of vertebrate genomes is tightly regulated to ensure accurate duplication, but our understanding of the interplay between genetic and epigenetic factors in this regulation remains incomplete. Here, we investigated the involvement of three…

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Veitia Lab – Dominant negative variants and cotranslational assembly of macromolecular complexes

L'équipe Veitia a récemment publié un nouvel article dans Bio Essays : Dominant negative variants and cotranslational assembly of macromolecular complexes Résumé : Pathogenic variants occurring in protein-coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency.…

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Palancade Lab – Puzzling out nuclear pore complex assembly

L'équipe Palancade a récemment publié un nouvel article dans FEBS Letters : Puzzling out nuclear pore complex assembly Résumé :  Nuclear pore complexes (NPCs) are sophisticated multiprotein assemblies embedded within the nuclear envelope and controlling the exchanges of molecules between the cytoplasm and the nucleus. In this review, we summarize the mechanisms by which these elaborate complexes…

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