L'équipe Raote a contribué à la publication d'une nouvelle revue dans Disease Models & Mechanisms : CYLD in health and disease Résumé : CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important roles in immunity and cancer. Complete CYLD ablation, truncation and expression of alternate isoforms, including short CYLD, drive distinct phenotypes and offer insights into CYLD…

L'équipe Gazave a récemment publié dans BMC Biology : The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes   Résumé : Background Explaining the emergence of the hallmarks of bilaterians is a central focus of evolutionary developmental biology—evodevo—and evolutionary genomics. For this purpose, we must both expand and also refine our knowledge of non-bilaterian…

L'équipe Guichet a récemment publié un article dans Development : Kinesin-1 promotes centrosome clustering and nuclear migration in the Drosophila oocyte Résumé : Microtubules and their associated motors are important players in nucleus positioning. Although nuclear migration in Drosophila oocytes is controlled by microtubules, a precise role for microtubule-associated molecular motors in nuclear migration has yet to be reported.…

L'équipe Jackson/Verbavatz a récemment publié dans Journal of Biomedical Optics : Enhanced neuroimaging with a calcium sensor in ex-vivo Drosophila melanogaster brains using closed-loop adaptive optics light-sheet fluorescence microscopy   Résumé : Significance Adaptive optics (AO) has been implemented on several microscopy setups and has proven its ability to increase both signal and resolution. However, reported configurations are not suited…

L'équipe Romet/Lemonne/Jégou a récemment publié dans Physical review : Models of vimentin organization under actin-driven transport Résumé : Intermediate filaments form an essential structural network, spread throughout the cytoplasm, and play a key role in cell mechanics, intracellular organization, and molecular signaling. The maintenance of the network and its adaptation to the cell's dynamic behavior relies on…

L'équipe Greenberg a récemment publié dans Development : Non-canonical imprinting in the spotlight   Résumé : Classical genomic imprints are regulated by parent-specific DNA methylation levels inherited from the gametes in mammals. Imprints control gene expression in a parent-of-origin manner and are essential for development. A distinct class of so-called ‘non-canonical’ imprints was recently discovered; these are…

Le nouvel article scientifique de l'équipe Doye a été publié en couverture et en highlight du journal Journal of Cell Science : Y-complex nucleoporins independently contribute to nuclear pore assembly and gene regulation in neuronal progenitors Résumé : Besides assembling nuclear pore complexes, the conduits of nuclear transport, many nucleoporins also contribute to chromatin organization and gene…

Dr. Sandra Duharcourt et Dr. Katja Wassmann L'Institut Jacques Monod est très fier de vous annoncer l'élection de Sandra Duharcourt et Katja Wassmann en tant que membre de la communauté de l'European Molecular Biology Organization (EMBO). Nous leur adressons toutes nos félicitations ! L'EMBO est une organisation internationale de chercheurs et chercheuses en sciences de la vie…

L'équipe Gazave a publié récemment dans Journal of Experimental Zoology part B: Molecular and developmental evolution : On the hormonal control of posterior regeneration in the annelid Platynereis dumerilii Résumé : Regeneration is the process by which many animals are able to restore lost or injured body parts. After amputation of the posterior part of its body, the annelid Platynereis…