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Romet-Lemonne/Jégou Lab – Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature structural & molecular biology : Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament   Résumé : Regulation of the assembly and turnover of branched actin filament networks nucleated by the Arp2/3 complex is essential during many cellular processes, including cell migration…

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Guichet Lab – The Importance of the Position of the Nucleus in Drosophila Oocyte Development

L'équipe Guichet a publié un nouvel article dans Cells : The Importance of the Position of the Nucleus in Drosophila  Oocyte Development Résumé : Oogenesis is a developmental process leading to the formation of an oocyte, a haploid gamete, which upon fertilisation and sperm entry allows the male and the female pronuclei to fuse and give rise to…

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Romet-Lemonne/Jégou Lab – Regeneration of actin filament branches from the same Arp2/3 complex

L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans Science Advances : Regeneration of actin filament branches from the same Arp2/3 complex Résumé : Branched actin filaments are found in many key cellular structures. Branches are nucleated by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to the side of preexisting “mother” filaments. Over time,…

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Symposium on cortical and spinal organoids

Symposium on cortical and spinal organoids - January 29th, 2024 The symposium on cerebral and spinal organoids is organised by the enSCORE platform of the Université Paris Cité (Labex "Who am I?", Institut Jacques Monod, Epigénétique et Destin Cellulaire) and the DIM C-BRAINS. It focuses on innovative 3D models of nervous system development in organoids derived from…

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Call for group leaders

 The Institut Jacques Monod (IJM), a leading center for fundamental interdisciplinary research in biology, is seeking to appoint at least two new group leaders.   The Institute comprises 28 international research groups working in the fields of biophysics, cell and developmental biology, evolution and genome biology. The IJM is affiliated with the Centre National de la Recherche…

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Séminaire IJM – Anaïs Bardet – 23/02/2024

Invité par l'équipe Gazave, Anaïs Bardet (CNRS, IGBMC, Strasbourg), présentera un séminaire IJM sur le thème : Transcription factor sensitivity to DNA methylation   Résumé : Multicellular organisms establish and maintain different transcriptional states in disparate cell types through complex and specific regulation of gene expression. This regulation is mediated by the cooperative binding of transcription factors to…

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Séminaire IJM – Alexander Palazzo – 02/02/2024

Invité par l'équipe Palancade, Alexander Palazzo (Biochemistry Department, University of Toronto / Laboratoire Interdisciplinaire des Science Numérique, Université Paris-Saclay) présentera un séminaire IJM sur le thème : How mRNA nuclear export allows you to live with a genome filled with junk DNA   Résumé : In eukaryotes, the division of the cellular space into nucleoplasm and cytoplasm promotes…

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Séminaire IJM – Mounia Lagha – 26/01/2024

Invitée par l'équipe Palancade, Mounia Lagha (Institut de Génétique Moléculaire de Montpellier) présentera un séminaire IJM : Lighting up the central dogma to dissect how sharp developmental patterns are established   "A fundamental question in biology is how cellular processes are so reproducible despite the inherent variations in the chemical reactions governing them. During development of a…

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Palancade Lab – On the edge: how nuclear pore complexes rule genome stability

L'équipe Palancade a publié une nouvelle review dans Current Opinion in Genetics & Development : On the edge: how nuclear pore complexes rule genome stability   Résumé : Nuclear organization has emerged as a critical layer in the coordination of DNA repair activities. Distinct types of DNA lesions have notably been shown to relocate at the vicinity…

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