The Dumont Lab contributed to a new article published in microPublication Biology:
Cell type-specific regulation by different cytokinetic pathways in the early embryo
Abstract:
Cytokinesis, the physical division of one cell into two, is typically assumed to use the same molecular process across animal cells. However, regulation of cell division can vary significantly among different cell types, even within the same multicellular organism. Using six fast-acting temperature-sensitive (ts) cytokinesis-defective mutants, we found that each had unique cell type-specific profiles in the early 2-cell through 8-cell C. elegans embryo. Certain cell types were more sensitive than others to actomyosin and spindle signaling disruptions, disrupting two members of the same complex could result in different phenotypes, and protection against actomyosin inhibition did not always protect against spindle signaling inhibition.
Connors CQ, Martin SL, Dumont J, Shirasu-Hiza M, Canman JC. Cell type-specific regulation by different cytokinetic pathways in the early embryo. MicroPubl Biol. 2024 Oct 22;2024:10.17912/micropub.biology.001316. doi: 10.17912/micropub.biology.001316. PMID: 39502424; PMCID: PMC11536048.