IJM Seminar – Matthias Peter

On June, Tuesday 18th, the Labex WHO AM I? invites Professor Matthias Peter (Institute of Biochemistry, ETH Zurich) to present an IJM Seminar on the theme:

Ubiquitin tails

Abstract:

We are interested in the function of E3-ubiquitin ligases orchestrating diverse cellular processes. For many years, we characterized the regulation and function of Cullin-RING E3 ligases (CRLs), which comprise the largest family of RING-based E3 ubiquitin ligases and catalyze approximately 20% of all ubiquitination reactions leading to proteasomal degradation. In this exposé, I will first summarize our recent attempts to understand specific functions of CUL4B-complexes, which are associated with X-linked intellectual disability (XLID). If time (and you..) permit/s, I will then discuss human CTLH/GID (hGID) E3 ligase complexes, which regulate G1 progression, mainly through their substrate-receptors Gid4 and Gid7/Wdr26. Using biochemical and cellular assays, we identified cognate hGID substrates involved in cell cycle progression, cell migration and metabolism.