Séminaire de l’Institut Jacques Monod – Kelly G. Ten Hagen

Invitée par l’équipe Courtier, Kelly G. Ten Hagen (Senior Investigator and Chief, Developmental Glycobiology Section, Associate Scientific Director for Diversity, Equity, Inclusion and Accessibility, National Institute of Dental and Craniofacial Research, National Institutes of Health, USA) présentera un Séminaire de l’Institut Jacques Monod sur le thème :

Mucins and O-glycosylation in Health and Disease

Résumé :

Mucins are evolutionarily conserved transmembrane and extracellular matrix molecules that mediate cell communication and signaling events, and also serve as a protective barrier on the external surface of cells.  Many of the unique functional properties of mucins are due to the abundant O-linked glycans present. Defects in mucin-type O-linked glycosylation are responsible for a number of diseases and are also associated with tumor progression and metastasis; HDL-cholesterol and triglyceride levels; congenital defects; and bone mineral density alterations.  Our research investigates the role of this conserved protein modification in normal organ development and function to gain a mechanistic understanding of how alterations in O-glycosylation and mucin biosynthesis contribute to disease susceptibility and progression.