Séminaire de l’Institut Jacques Monod – Mateusz C. Ambrozkiewicz

Invité par l’équipe Konstantinides, Dr. Mateusz C. Ambrozkiewicz, FENS-Kavli Scholar (Institute for Cell Biology and Neurobiology, Charité University Hospital, Berlin, Germany) présentera un sémininaire de l’Institut Jacques Monod sur le thème :

Proteostatic Mechanisms of Cellular Diversification in the Developing Brain

Résumé :

Formation of functional circuits in the adult brain is a biological fundament for its executive role in the living organism and requires specification of neurons, their correct positioning, formation of dendrites and synapses. In this talk, I will present our current research on the translational mechanisms and post-translational modifications orchestrating neuronal diversification in the developing brain. Particularly, I will shed light on the specific post-transcriptional requirements for neuronal progenitors, including the dynamics of protein synthesis as well as the role of ubiquitination-dependent degradation in healthy and diseased brain. I will show how deciphering a molecular mechanism at the basis of neurodevelopmental disease etiology can be used to propose therapeutic strategy impinging on modulating the activity of cellular proteostasis effectors, such as the E3 ubiquitin ligases.