Séminaire de l’Institut Jacques Monod – Yohanns Bellaiche

Invité par l’équipe Ladoux / Mege, Yohanns Bellaiche (Institut CURIE UM3215 U934, Equipe Polarité Division Morphogenèse) va présenter un séminaire de l’Institut Jacques Monod sur le thème :

How epithelial shaping is tailored by cell and tissue size

Résumé :

Everywhere Nature works true to scale, and everything has its proper size accordingly » – with these words, D’Arcy Thompson in « On Growth and Form » elegantly captured one of biology’s profound mysteries: the scaling of biological structures and substructures with size (length, area, or volume). At the cellular level, scaling plays central roles in organelle dynamics during cell division and metabolic regulation. At the organismal level, studies of scaling properties have led to discoveries in animal physiology, bone and limb proportions, and gene expression patterns.

In this seminar, I will present our recent work linking cell and tissue size to the morphodynamics of tissue development. First, I will discuss our findings on the mechanisms by which cells probe their size to scale their geometrical and mechanical properties, thereby regulating cell proliferation and apoptosis. Then, I will describe how tissue morphogenesis adapts to overall animal size to ensure robust and invariant development across the physiological range of sizes within a species.