Séminaire IJM – Matthias Peter

Le mardi 18 juin 2024, le Labex WHO AM I? invite le Professeur Matthias Peter (Institute of Biochemistry, ETH Zurich) pour présenter un séminaire de l’Institut Jacques Monod sur le thème :

Ubiquitin tails

Résumé :

We are interested in the function of E3-ubiquitin ligases orchestrating diverse cellular processes. For many years, we characterized the regulation and function of Cullin-RING E3 ligases (CRLs), which comprise the largest family of RING-based E3 ubiquitin ligases and catalyze approximately 20% of all ubiquitination reactions leading to proteasomal degradation. In this exposé, I will first summarize our recent attempts to understand specific functions of CUL4B-complexes, which are associated with X-linked intellectual disability (XLID). If time (and you..) permit/s, I will then discuss human CTLH/GID (hGID) E3 ligase complexes, which regulate G1 progression, mainly through their substrate-receptors Gid4 and Gid7/Wdr26. Using biochemical and cellular assays, we identified cognate hGID substrates involved in cell cycle progression, cell migration and metabolism.