On June, Tuesday 18th, the Labex WHO AM I? invites Professor Matthias Peter (Institute of Biochemistry, ETH Zurich) to present an IJM Seminar on the theme:
Ubiquitin tails
Abstract:
We are interested in the function of E3-ubiquitin ligases orchestrating diverse cellular processes. For many years, we characterized the regulation and function of Cullin-RING E3 ligases (CRLs), which comprise the largest family of RING-based E3 ubiquitin ligases and catalyze approximately 20% of all ubiquitination reactions leading to proteasomal degradation. In this exposé, I will first summarize our recent attempts to understand specific functions of CUL4B-complexes, which are associated with X-linked intellectual disability (XLID). If time (and you..) permit/s, I will then discuss human CTLH/GID (hGID) E3 ligase complexes, which regulate G1 progression, mainly through their substrate-receptors Gid4 and Gid7/Wdr26. Using biochemical and cellular assays, we identified cognate hGID substrates involved in cell cycle progression, cell migration and metabolism.
The séminar will take place on June, Tuesday 18th at 11.45 am in room François Jacob ( 15 rue Hélène Brion 75013 Paris)
