The Minc Lab contributed to the publication of a new article in Biophysical Journal :
A physical model for M1-mediated influenza A virus assembly
Abstract:
Influenza A virus particles assemble at the plasma membrane of infected cells. During assembly all components of the virus come together in a coordinated manner to deform the membrane into a protrusion eventually forming a new, membrane-enveloped virus. Here we integrate recent molecular insights of this process, particularly concerning the structure of the matrix protein 1 (M1), within a theoretical framework describing the mechanics of virus assembly. Our model describes M1 polymerization and membrane protrusion formation, explaining why it is efficient for M1 to form long strands assembling into helices in filamentous virions. Eventually, we find how the architecture of M1 helices is controlled by physical properties of viral proteins and the host cell membrane. Finally, by considering the growth force and speed of viral filaments, we propose that the helical geometry of M1 strands might have evolved to optimize for fast and efficient virus assembly and growth.
Peukes J, Dmitrieff S, Nédélec FJ, Briggs JAG. A physical model for M1-mediated influenza A virus assembly. Biophys J. 2024 Nov 20:S0006-3495(24)00739-2. doi: 10.1016/j.bpj.2024.11.016. Epub ahead of print. PMID: 39573879.