L’équipe Doye a publié un article dans Current Opinion in Cell Biology :
Opening the gate: Complexity and modularity of the nuclear pore scaffold and basket
Résumé :
Nuclear pore complexes (NPCs) are giant molecular assemblies that form the gateway between the nucleus and the cytoplasm and accommodate the bidirectional transport of a large variety of cargoes. Recent years have seen tremendous advances in our understanding of their building principles and have in particular called attention to the flexibility and variability of NPC composition and structure. Here, we review these recent advances and discuss how the newest technologies push the boundaries of nuclear pore research forward, with a specific highlight on the NPC scaffold and a prominent pore appendage, the nuclear basket, whose architecture has long been elusive.
Dultz E, Doye V. Opening the gate: Complexity and modularity of the nuclear pore scaffold and basket. Curr Opin Cell Biol. 2025 Jan 17;92:102461. doi: 10.1016/j.ceb.2024.102461. Epub ahead of print. PMID: 39826239.