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Human neurodevelopment and disorders

ERL1340

Vanessa RIBES / Stéphane NEDELEC

Our IJM team, also recognised as an INSERM-labelled research team (ERL1340), investigates the mechanisms underlying both normal and pathological development of the nervous system, particularly within the spinal cord and brainstem. Our goal is to elucidate how signalling pathway dynamics and transcriptional programmes orchestrate cell diversity and morphogenesis during neural tube formation. Furthermore, we decipher how rare genetic mutations disrupt these processes, leading to paediatric disorders. To address these questions, we develop organoid models derived from pluripotent stem cells, capable of recreating the cellular diversity and complex organisation of the embryonic spinal cord in mice and humans.

To address these questions, we develop organoid models derived from pluripotent stem cells, capable of recreating the cellular diversity and complex organization of the murine or human embryonic spinal cord.

Keywords: embryo, spinal cord, organoids, human and murine pluripotent stem cells, iPSC, development, signaling pathways, transcription factors, cell fates

 +33 (0)1 57 27 81 93   Contact Vanessa Ribes Contact Stéphane Nedelec