Invité par l’équipe Borghi, Marie Breau (CRCN INSERM, Institut de Biologie Paris-Seine (IBPS), Sorbonne Université, Laboratoire de Biologie du Développement) présentera un Séminaire de l’Institut Jacques Monod sur le thème :
Mechanical interactions between tissues during the morphogenesis of the zebrafish olfactory placode
Résumé :
Neuronal circuit assembly requires neuronal migration and axon/dendrite growth, which are believed to be primarily guided by chemical cues. Yet the movement of neurons and their protrusions is influenced by mechanical cues, whose functions have started to be studied in vitro, but remain largely unexplored in vivo. During development, neurons are embedded in neuroepithelia or neuronal clusters (placodes, ganglia) which undergo morphogenetic reorganisation in coordination with surrounding tissues. These adjacent tissues can exert pushing or pulling forces on the neuronal cell bodies or their growing protrusions, thus influencing the final position of the neurons, but also their morphology and connectivity. Conversely, growing neurons or groups of neurons may influence the morphogenesis of nearby tissues through the transmission of forces. I will present how we investigate the role and mechanisms of this kind of tissue-tissue mechanical interplay using as a model the zebrafish olfactory circuit, which develops in the olfactory placode in a superficial location allowing easy live imaging and mechanical perturbations.
Le séminaire aura lieu le vendredi 26 avril 2024 à 11h45 en salle François Jacob.