Le mardi 18 juin 2024, le Labex WHO AM I? invite le Professeur Matthias Peter (Institute of Biochemistry, ETH Zurich) pour présenter un séminaire de l’Institut Jacques Monod sur le thème :
Ubiquitin tails
Résumé :
We are interested in the function of E3-ubiquitin ligases orchestrating diverse cellular processes. For many years, we characterized the regulation and function of Cullin-RING E3 ligases (CRLs), which comprise the largest family of RING-based E3 ubiquitin ligases and catalyze approximately 20% of all ubiquitination reactions leading to proteasomal degradation. In this exposé, I will first summarize our recent attempts to understand specific functions of CUL4B-complexes, which are associated with X-linked intellectual disability (XLID). If time (and you..) permit/s, I will then discuss human CTLH/GID (hGID) E3 ligase complexes, which regulate G1 progression, mainly through their substrate-receptors Gid4 and Gid7/Wdr26. Using biochemical and cellular assays, we identified cognate hGID substrates involved in cell cycle progression, cell migration and metabolism.
Le séminaire aura lieu mardi 18 juin à 11h45 en salle François Jacob ( 15 rue Hélène Brion 75013 Paris)
