L’équipe Veitia a publié une nouvelle revue dans Trends in biochemical sciences :
Rethinking transcription factor dynamics and transcription regulation in eukaryotes
Résumé :
Transcription factors (TFs) control gene expression by binding to specific DNA motifs in cis-regulatory elements. Cooperativity has been thought to ensure TF binding specificity. Recent research suggests that, at least in yeast, the role of cooperativity has probably been overemphasized. Consequently, synergy – the collective recruitment of the transcriptional machinery by TFs bound at multiple DNA sites – emerges as a more significant mechanism for achieving the specificity of the transcriptional response. Furthermore, I argue that the concentration of TFs within phase-separated nuclear condensates and their covalent modifications play an underappreciated but crucial role in sharpening transcriptional responses through complementary mechanisms. A model integrating cooperativity, synergy, post-translational modifications, and phase separation provides a comprehensive framework to explain dynamic, context-specific transcriptional responses in eukaryotes.
Veitia RA. Rethinking transcription factor dynamics and transcription regulation in eukaryotes. Trends Biochem Sci. 2025 Mar 4:S0968-0004(25)00027-1. doi: 10.1016/j.tibs.2025.01.012. Epub ahead of print. PMID: 40044550.